Hypersensitivity to endotoxin hepatotoxicity in rats with inflammatory lesions

Summary The ratio of sinusoidal nonparenchymal cells to hepatocytes in rat liver was significantly increased following induction of inflammation, and decreased after subsequent exposure to endotoxin, particularly in the region around the terminal portal venules. Rats with inflammatory lesions were more sensitive to endotoxin hepatocytotoxicity than normal controls, as judged from the dose-dependent increase in activity of serum transaminases and from the extent of liver tissue injury. In addition, these animals, which were already in a state of depletion of hepatic glycogen, demonstrated marked hyperglycemia 24 h after endotoxin administration in small doses of less than 2 mg/kg.     

A comparison of the effects of the optical isomers of isoproterenol on energy metabolism in a mouse sarcoma

Summary Disturbance to energy production in the S180 sarcoma (CB) by optical isomers of isoproterenol was assessed from altered adenine nucleotide levels at 1 h. The L-isomer almost halved the ATP level and lowered the energy charge significantly; the D-isomer was inactive. Dependence of tumor injury on cytochrome P-450 activity appears unlikely.One of us (GRNJ) thanks the Department of Surgery, Medical School, Kings's College Hospital, London, England, for the provision of experimental facilities; the Institute of Biochemistry, German Cancer Research Centre, Heidelberg, FRG, for permitting the measurement of metabolites; the Cancer Research Campaign, London, UK, for a part-time grant; and Zyma GmbH, München, FRG, and the estate of the late Dr Lucie Polak for additional financial support.     

基于有限元模型的人体损伤脊柱的动态特性分析

为了研究在全身振动情况下损伤脊椎对其相临组织部件的影响,建立了一个腰椎L3-L5段的三维非线性有限元模型.研究对脊椎给予了几种损伤假设,如小关节切除、去髓核和后部结构切除等,并对这几种损伤情况进行了有限元瞬态分析.结果表明,腰椎在振动过程中不仅存在垂直方向的振动还伴随有仰俯运动.脊椎小关节可以限制腰椎仰俯运动的幅度以保护纤维环后部免受大的拉伸和高应力的危害.椎间盘去髓核会导致纤维环上高应力的产生和椎间盘鼓胀增大.在振动过程中,小关节的切除同样可以加速椎间盘的退化.     

中西医结合治疗原发性肾病综合症的临床研究

目的:观察中西医结合治疗原发性肾病综合症的临床疗效,并初步探讨其机理.方法:选择68例中医辨证为脾肾阳虚兼挟血瘀湿浊的PNS患者,随机分对照组33例,用标准激素治疗.治疗组35例,在标准激素治疗基础上加服中药汤剂.结果:治疗组能明显改善症状和体征,减少尿蛋白,降低血粘度及血脂水平(P均＜0.01).治疗组总有效率达91.42%,明显优于对照组78.78%(P＜0.01).     

碘硒氟联用对小鼠肝肾脂褐素含量的影响

为研究碘、硒、氟联用对小鼠肝脏和肾脏脂褐素含量的影响,让小鼠饮用加氟、加碘和加硒的溶液10周后,采用生化方法测定其肾脏和肝脏组织内脂褐素含量的变化.结果表明,高氟能导致小鼠肝脏和肾脏内脂褐素含量显著上升(P<0.05);适当量的碘或碘硒联用可引起小鼠肝脏和肾脏脂褐素含量显著下降(P<0.05),而碘量过高则与氟产生协同毒性作用.结果提示,一定量的碘或碘硒联用可改善氟致肝脏和肾脏组织抗氧化能力的损伤.     

磷酸缓冲液对大豆种子萌发期抗冷性的影响

用0.01mol/L的pH5.8磷酸缓冲液浸种9h,可在大豆种子萌发期低温胁迫((3±1）℃,24h)条件下,能有效地降低相对电导率,水溶性蛋白含量和稀碱提取蛋白含量明显增加,脯氨酸含量也显著增加.表明磷酸缓冲液浸种对大豆种子萌发期在低温胁迫时,具有防护作用.     

110例大腿肌拉伤针刺拨罐疗效分析

针刺加拔罐治疗大腿肌拉伤伴有皮下青紫瘀血者,解痉止痛效果好,见效快。但须注意疼痛缓解后还需继续治疗,并嘱患者制动、忌冷浴。在治疗后期避免剧烈活动,防止形成不可逆转的病变。     

火车致闭合性腹外伤63例分析

火车致闭合性腹外伤，常为多个脏器损伤，且以实质性脏器破裂多见，病情危急，多死于创伤性失血性休克，B超及腹穿是早期明确诊断的重要手段，抗休克、及时剖腹手术是抢救患者生命的关键。     

论医疗损害违法行为与损害后果之间的因果关系

由于医疗过程的复杂性与人类认识能力的局限性,在认定医疗损害的违法行为与损害后果之间的因果关系时更会遇到很多的困难.笔者认为,在探究治疗行为与损害结果因果关系的过程中,应按照二分法的一般规则,在步骤上,分二步走.首先,考察事实因果关系,其次,考察法律因果关系.特殊情况下运用相当因果关系及盖然性加以认定.其中,占据最重要地位的是盖然性因果关系理论.     

中学生篮球运动中踝关节损伤的原因及预防

对玉林市五所中学经常从事篮球运动的中学生采用临床调查分析和数理统计等方法,了解到篮球运动中踝关节的损伤较为常见.其损伤的原因主要包括技术动作不合理、忽视准备活动、锻炼、训练和比赛安排不合理、场地器材不符合体育卫生标准等,为了预防损伤,学生与教师必须密切配合,课前重视准备活动;教师合理安排场地器械,注重科学的体育教学原则.